SATILAGE 750mg

Satilage is indicated in adults for the temporary relief of symptoms in mild to moderate osteoarthritis of the knee.

Posology

• Adult only take 2 – 4 capsules daily or as directed by your heathcare professional

 Paediatric population

• Satilage should not be used in children and adolescents below the age of 18 (see 4.4).

Elderly

• No specific studies have been performed in the elderly, but according to clinical experience dosage adjustment is not required when treating otherwise healthy, elderly patients.

Impaired renal and/or liver function

• In patients with impaired renal and/or liver function no dose recommendations can be given, since no studies have been performed.

Method of administration
Capsules can be taken with or without food.
 

Pregnancy

• Although no specific human studies have been conducted, shark cartilage should be avoided in pregnant or lactating women, due to risk of impaired angiogenesis (other antiangiogenic agents, such as thalidomide, are known teratogens).

 Breast Feeding

• There is no data available on the excretion of glycosaminoglycans presented in shark cartilage in human milk. No recommended as there is no data on the safety of the newborn.

The most common adverse reactions associated with treatment with shark cartilage are nausea, abdominal pain, indigestion, constipation, diarrhoea, headache and tiredness. In addition rash, itching, and flushing have been reported.  The reported adverse reactions are usually mild and transitory.
 
The adverse reactions are classified according to frequency of observation: Very common: ≥ 1/10, Common ≥ 1/100, No Common ≥ 1 / 1,000 - ≤1 / 100 Rare: ≥ 10,000 - <1 / 1,000, Very rare <1 / 10,000 , unknown ( cannot be estimated on statistics)
 
Adverse reactions are grouped by system organ class:

• Common ≥ 1/100: as nervous system disorders (headache, fatigue), digestive disorders (abdominal pain, vomiting, diarrhea or constipation )
• Uncommon ≥ 1 / 1,000 - ≤1 / 100: skin disorders (redness, itching)
• Unknown: allergy, insomnia, dizziness, asthma, vomiting, jaundice.

 
Sporadic, spontaneous cases of hypercholesterolaemia have been reported, but causality has not been established.
 
Patients with diabetes mellitus
Blood glucose control worsened in patients with diabetes mellitus. Frequency not known.
 

Pharmacotherapeutic group: Other anti-inflammatory and anti-rheumatic agents, non-steroidal anti-inflammatory drugs.
ATC code: M01AX05
 
Shark cartilage contains approximately

• 40% protein (troponin-I, tetranectin-type protein, collagenase, cartilage-derived inhibitor/CDI, tissue inhibitor of metalloproteinases),
• 5-20% glycosaminoglycans (chondroitin sulfate-D, chondroitin-6-sulfate, keratan sulfate)
• The remainder is made up of calcium salts (up to 25% of some preparations) and glycoproteins (sphyrnastatin-1 and 2, galactosamines, glucosamine)

 
Shark cartilage may be useful in inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and, in some cases, osteoarthritis. Specifically, it may be beneficial due to its anti-angiogenic effects as well as the presence of high levels of anti-inflammatory mucopolysaccharides such as glucosamine sulfate and chondroitin sulfate. Improvements in inflammation may be noticed as soon as 1 to 2 weeks after initiating treatment with shark cartilage; however, if no improvement occurs, patients should be advised to continue treatment for 6 to 8 weeks before a decision is made to discontinue.
 
Mechanism of action

• Exactly how shark cartilage works to achieve these results is not completely understood. One possibility that has been investigated is that chondroitin sulfate, one of the most plentiful glycosaminoglycans found in cartilage, may be one of the active ingredients for this role. This makes sense when considering that chondroitin acts like a liquid magnet, attracting fluid into the proteoglycans (i.e, large molecules that trap water like a sponge and make cartilage resilient22). This fluid acts as a shock absorber and also brings nutrients with it into the cartilage. Perhaps of greater significance than its fluid-enhancing properties, chondroitin sulfate protects existing cartilage from premature breakdown by inhibiting certain cartilage-chewing enzymes. Furthermore, chondroitin stimulates the production of proteoglycans and collagen that are needed for healthy new cartilage. Research on chondroitin sulfate has demonstrated that it is effective in the treatment of osteoarthritis.
• Studies were conducted in several different countries, but the results were always the same: patients treated with chondroitin sulfate experienced significant relief of pain, and enjoyed increased mobility

Below 30⁰C in dry place, prevent direct sunlight.
Keep out of reach of children.
Do not use medicine beyond the expiry date indicated on the label or when the packaging is damaged.

 AUST L 82334